Triptolide Effects on Cognitive Impairment in APP/PS1 Alzheimer's Mouse Model

Triptolide treatment significantly improved spatial learning and memory in Alzheimer's Disease model mice during Morris Water Maze tests. The dataset includes results on synaptic plasticity, amyloid-beta levels, and autophagic activity from a preclinical study by xinyao Qi, last updated in May 2026. It is a 9.2 MB collection of files shared under a CC-BY-4.0 license on figshare.

Use Cases

• Analyze the relationship between Triptolide administration and cognitive test performance based on Morris Water Maze results.
• Investigate correlations between compound treatment and levels of synaptic proteins like PSD95 and SYP.
• Model the multi-target pharmacological effects of Triptolide on autophagy pathways in Alzheimer's pathology.
• Validate preclinical findings on amyloid-beta peptide reduction following neuroprotective treatment.

Strengths

• Data originates from a controlled preclinical study using the established APP/PS1 transgenic mouse model.
• Includes multiple measured endpoints: cognitive behavior, synaptic plasticity, protein levels, and autophagic activity.
• Shared under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• Row count and specific column definitions are unknown, limiting suitability assessment for direct analysis.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect the specific experimental conditions and model inherent to the single study source.

Provenance

Source

xinyao Qi via figshare

Collection Method

Experimental data from a study on Triptolide treatment in an APP/PS1 transgenic mouse model of Alzheimer's Disease.

Freshness

Last updated 2026-05-05 09:11:47; freshness should be verified.