Baicalein Against Candida Auris: Transcriptomic Analysis of Antifungal Mechanisms

Baicalein demonstrates potent antifungal activity against Candida auris with a minimum inhibitory concentration of 1 μg/mL. This dataset contains transcriptomic sequencing results identifying 11 adhesion- and biofilm-associated target genes, including SCF1 and ALS1, as pivotal regulators. It provides experimental support for developing novel antifungal agents by elucidating how baicalein suppresses virulence factors and biofilm formation.

Use Cases

• Identifying gene expression changes in Candida auris under baicalein treatment based on transcriptomic sequencing.
• Analyzing the suppression of virulence factors and biofilm formation based on experimental assessments of adhesion and growth.
• Validating in vivo protective efficacy of a compound based on results from a Galleria mellonella infection model.
• Comparing antifungal activity metrics (MIC, MFC, SMIC) across multiple Candida auris isolates.

Strengths

• Dataset is derived from a structured experimental study assessing multiple antifungal activity metrics (e.g., MIC of 1 μg/mL).
• Transcriptomic analysis identified 11 specific target genes related to adhesion and biofilm, providing mechanistic insight.
• Data is openly licensed under CC-BY-4.0, facilitating reuse and redistribution.

Limitations

• Column names and row counts are not provided, limiting understanding of the data's internal structure.
• The dataset's size (203,135 bytes) suggests it may be a summary or processed results file, not raw sequencing reads.
• The 'Last updated' date is in the future (2026-03-24), indicating a metadata error that casts doubt on temporal accuracy.

Provenance

Source

Research study on the antifungal effects of baicalein against Candida auris.

Collection Method

Experimental assessment including transcriptomic sequencing, in vitro antifungal activity tests, and in vivo Galleria mellonella model.

Time Range

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Freshness

2026-03-24 (Note: This date is in the future and is likely a metadata error.)

Geography

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