Babelgene: Gene Ortholog Mappings for Model Organisms

An R package dataset for converting between human and non-human gene orthologs. It integrates orthology predictions from multiple databases as compiled by the HGNC Comparison of Orthology Predictions (HCOP). The package was authored by Igor Dolgalev and is sourced from the paperswithcode platform.

Use Cases

• Harmonizing gene names for cross-species analysis based on integrated orthology predictions.
• Translating human gene identifiers to model organism equivalents for comparative genomics.
• Converting model organism gene identifiers to human orthologs for leveraging human-derived databases.

Strengths

• Integrates orthology assertions from multiple source databases.
• Provides a tidy data format designed for ease of use in genomic analysis.
• Specifically addresses the need for harmonization between human and model organism gene spaces.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

HGNC Comparison of Orthology Predictions (HCOP), integrated via the babelgene R package.

Collection Method

Compilation of orthology assertion predictions from multiple databases.