Benzalkonium Chloride Nephrotoxicity in Kidney-on-a-Chip Transcriptomics

Transcriptomic analysis reveals focal adhesion and cholesterol biosynthesis pathways were significantly altered in proximal tubule epithelial cells exposed to benzalkonium chloride. Marie N. Brzoska published this dataset on figshare in May 2026, containing data from a 3D microphysiological system and 2D cell cultures. The 1.8 MB Excel file likely contains gene expression or pathway analysis results.

Use Cases

• Analyze transcriptomic pathway alterations based on focal adhesion and cholesterol biosynthesis changes mentioned in the description
• Compare nephrotoxicity effects based on exposure to C12- or C14-BAC at 100 nM for 1 week
• Validate phenotypic changes in proximal tubule epithelial cells using orthogonal techniques described

Strengths

• Data includes transcriptomic analysis from a novel 3D kidney-on-a-chip system
• Exposure conditions are specified: C12- or C14-BAC at 100 nM for 1 week
• File size is 1.8 MB, indicating a focused dataset

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect experimental bias inherent to the specific cell culture and figshare platform

Provenance

Source

figshare

Collection Method

Experimental data from 2D cell cultures and a 3D kidney-on-a-chip microphysiological system.

Freshness

Last updated 2026-05-25 17:03:27; freshness should be verified