Berkeleylactam A: Synthetic Antibiotic Derivative with Stability and MIC Data

Berkeleylactam A is a synthetic 16-membered macrolide analog designed for enhanced stability over its natural counterpart, berkeleylactone A. The dataset, published by John H. Hoody in April 2026, includes in vitro MIC values and plasma stability half-lives for both compounds. It also contains the X-ray crystallography structure file confirming the synthetic analog's design.

Use Cases

• Compare in vitro antimicrobial activity based on reported MIC values for berkeleylactone A and berkeleylactam A
• Analyze plasma stability improvements based on the reported 40-fold increase in half-life for the synthetic analog in mouse plasma
• Study synthetic tractability and structural confirmation based on the ten-step synthesis and X-ray crystallography data mentioned
• Investigate metabolic degradation pathways based on the described glutathione conjugation findings for both compounds

Strengths

• Includes specific quantitative metrics: MIC values ranging from 0.8 to 2.5 μg/mL and plasma half-lives of 3.5 and 140 minutes
• Provides structural confirmation via an X-ray crystallography file (CIF format)
• Directly compares a natural compound with a designed synthetic analog for stability and activity

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download
• The dataset is very small at 835.6 KB, indicating limited scope
• Data may reflect the specific experimental bias inherent to the single study described

Provenance

Source

figshare

Collection Method

Experimental synthesis and characterization in a research study

Time Range

Experimental data from the described study; publication date 2026

Freshness

Last updated 2026-04-23 17:34:17; freshness should be verified

Geography

Compound origin referenced to the Berkeley Pit in Butte, MT, USA