Three Novel Toxin-Producing Clostridioides Species from Human Diarrhea Patients

Five bacterial isolates from patients with suspected Clostridioides difficile infection were characterized. The dataset includes integrated genomic, proteomic, and phenotypic analyses confirming three novel species. It was authored by Daniela Aguilar and last updated on May 7, 2026.

Use Cases

• Comparative genomic analysis based on the novel PaLoc architectures encoding TcdB7 or TcdB11
• Studying niche specialization within the human gut based on described carbon utilization profiles and exoproteomes
• Assessing virulence attenuation relative to reference strains based on functional assay results from murine models
• Refining diagnostic workflows for diarrheal diseases based on the discovery of toxin-producing species lacking the tcdC marker

Strengths

• Integrated multi-omics data including genomic, proteomic, and phenotypic analyses.
• Includes functional assay results confirming toxin activity and cytotoxicity.
• Data is openly licensed under CC-BY-4.0.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 6.4 MB, indicating limited scale.

Provenance

Source

figshare

Collection Method

Isolates were derived from five distinct patients with suspected CDI cases that tested negative for the tcdC PaLoc marker.

Freshness

Last updated 2026-05-07 10:54:15; freshness should be verified.