Adolescent Obesity Metabolomics: DDE Exposure and Weight Loss After Bariatric Surgery

60 adolescents with severe obesity were studied longitudinally before and after bariatric surgery. Metabolomic profiles from plasma and adipose tissue were analyzed using gas/liquid chromatography and high-resolution mass spectrometry to identify metabolic signatures linking DDE exposure to weight loss outcomes. The dataset, authored by Zhenjiang Li and last updated in 2026, contains results from metabolome-wide association analyses.

Use Cases

• Identify metabolic mediators between DDE exposure and BMI changes based on the described meet-in-the-middle analysis approach.
• Study longitudinal changes in plasma metabolite profiles based on samples collected at surgery, 6 months, 1 year, and 3 years postoperatively.
• Analyze associations between persistent organic pollutants in adipose tissue and local metabolic alterations based on quantified p,p′-DDE concentrations.
• Investigate potential biomarkers like methylbutyroyl-carnitine that may attenuate surgical efficacy based on the findings described.

Strengths

• Longitudinal design with plasma samples collected at four time points over 3 years.
• Multi-tissue analysis includes both visceral adipose tissue and plasma metabolomics.
• Analysis employed high-resolution mass spectrometry and a series of metabolome-wide association studies.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The sample size of 60 adolescents may limit generalizability.

Provenance

Source

figshare

Collection Method

Longitudinal study involving gas/liquid chromatography and high-resolution mass spectrometry analysis of samples from bariatric surgery patients.

Time Range

Covers samples collected at surgery and up to 3 years postoperatively.

Freshness

Last updated 2026-05 04 22:13:33; freshness should be verified.

Geography

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