Human Kir7.1 Ion Channel Structures in Three Conformations

Figshare provides three structural models of the essential human potassium channel Kir7.1, authored by Qingwei Niu. The dataset contains atomic coordinate files for conformations labeled 9PR5_extended, 9PR6_docked, and 9PR7_ENT17OHPC. It was last updated in March 2026.

Use Cases

• Compare the Kir7.1 channel conformations 9PR5_extended, 9PR6_docked, and 9PR7_ENT17OHPC to study lipid-mediated structural regulation.
• Use the 9PR7_ENT17OHPC structure to model interactions between Kir7.1 and bioactive lipid molecules.
• Perform molecular dynamics simulations using the provided Kir7.1 structures to analyze functional ion channel dynamics.
• Integrate the docked 9PR6 structure for virtual screening studies targeting the Kir7.1 binding site.

Strengths

• Includes three distinct, experimentally derived or modeled structures of a human ion channel.
• Dataset size is 1.6 GB, providing detailed atomic coordinate data for structural analysis.
• Released under a permissive CC BY 4.0 license for broad reuse.

Limitations

• Contains only three structural snapshots, limiting statistical analysis of conformational diversity.
• Lacks accompanying functional or electrophysiological data to correlate structures with channel activity.
• Sample data and column definitions are unavailable, complicating automated parsing.

Provenance

Source

figshare

Collection Method

Structural biology techniques, likely involving cryo-electron microscopy or molecular modeling.

Time Range

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Freshness

Last updated March 2026.

Geography

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