Systematic Review and Meta-Analysis of Pamidronate for CRPS I Treatment

Anas R. Alashram's systematic review and meta-analysis evaluates the effectiveness of intravenous pamidronate for Complex Regional Pain Syndrome Type I (CRPS I). The work, last updated in April 2026, synthesizes evidence from seven studies identified through searches of seven major databases up to October 2025. The meta-analysis of three studies showed a non-significant effect size with high heterogeneity, indicating preliminary findings.

Use Cases

• Evaluating treatment efficacy for pain reduction based on the review's focus on pain outcomes
• Assessing functional improvement in CRPS I patients based on described functional outcomes
• Analyzing dosing strategies for bisphosphonate therapy based on the described focus on dosing
• Conducting secondary meta-analyses on CRPS treatments based on the provided statistical results and study quality assessments

Strengths

• Study quality was formally assessed using three established tools (PEDro scale, ROBINS-I, Newcastle-Ottawa Scale)
• Search strategy covered seven major academic databases (PsycINFO, PubMed, EMBASE, SCOPUS, Web of Science, PEDro, CINAHL)
• Meta-analysis results include specific statistical measures (Cohen’s d = 0.722, I² = 88%)

Limitations

• The dataset is a 74.8 KB text document, indicating a very limited scope of raw data
• The meta-analysis is based on only three studies, with high heterogeneity and a wide prediction interval
• Column-level documentation is absent; field semantics must be inferred after download

Provenance

Source

figshare, author Anas R. Alashram

Collection Method

Systematic literature review and meta-analysis of published studies.

Time Range

Literature search conducted until October 2025.

Freshness

Last updated 2026-04-17 18:12:21

Geography

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