Fungal Pseudophosphatase Catalog and Scanner Tool for Genome-Wide Analysis

A catalog of fungal pseudophosphatases compiled from literature, databases, and systematic scans of three pathogenic fungi. The dataset includes a classification into 10 distinct groups, with three groups identified as fungal-specific. It is accompanied by the Pseudophosphatase Scanner, a bioinformatics pipeline for genome-wide detection, available as a Python script and Google Colab notebook.

Use Cases

• Identify potential antifungal drug targets based on fungal-specific pseudophosphatase groups with no human homologues.
• Analyze the conservation of pseudophosphatase candidates across humans, true yeasts, and filamentous fungi.
• Perform genome-wide pseudophosphatase detection using the provided HMM scan and motif-matching pipeline.
• Study the role of pseudophosphatases in fungal signaling pathways regulating development, metabolism, and virulence.

Strengths

• Includes a systematic scan of phosphatomes from three pathogenic fungi: Cryptococcus neoformans, Fusarium graminearum, and Talaromyces marneffei.
• Provides a concrete bioinformatics tool (Pseudophosphatase Scanner) for analysis, available in multiple execution formats.
• Classifies candidates into 10 distinct groups, offering a structured framework for analysis.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (13.1 KB), indicating limited scope or summary-level data.

Provenance

Source

figshare

Collection Method

Integrated from literature, databases, and systematic genome scans.

Freshness

Last updated 2026-05-12 02:29:27