Bufalin Effects on Renal Ferroptosis and Fibrosis in Diabetic Kidney Disease Models

Research data from a 2026 study investigating the therapeutic effects of bufalin on diabetic kidney disease models. The dataset includes analysis of tubulointerstitial fibrosis and ferroptosis-related markers in db/db mice and renal tubular epithelial cells under high glucose conditions. It was authored by Yunyang Qiao and shared under a CC-BY-4.0 license.

Use Cases

• Analyzing the relationship between ferroptosis and tubulointerstitial fibrosis based on marker expression data.
• Validating the post-transcriptional suppression of STAT3 by bufalin based on molecular docking and luciferase assay results.
• Investigating the therapeutic potential of ferroptosis inhibitors like ferrostatin-1 based on experimental outcomes.

Strengths

• Includes data from both in vivo (db/db mice) and in vitro (high glucose-induced RTECs) models.
• Employs multiple validation methods including network pharmacology, molecular docking, and dual-luciferase reporter assays.
• Shared under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 1.4 MB size suggests a small dataset, potentially limiting statistical power.

Provenance

Source

Yunyang Qiao via figshare.

Collection Method

Experimental analysis of diabetic kidney disease models.

Freshness

Last updated 2026-05-26 08:00:03.