Zebrafish Ventricle RNA-Seq After Myocardial Infarction

A 2024 study provides bulk RNA sequencing data from isolated zebrafish ventricles following myocardial infarction or sham treatment. It compares wild-type and tlr3 loss-of-function mutants at 1 and 4 days post-injury. The dataset supports analysis of genetic pathways involved in cardiac regeneration.

Use Cases

• Differential gene expression analysis based on time points post-myocardial infarction
• Pathway enrichment studies to investigate the role of tlr3 in cardiac regeneration
• Comparative transcriptomics between wild-type and tlr3-/- mutant zebrafish
• Validation of findings from the associated BioRxiv preprint (DOI: 10.1101/2024.04.12.589327)

Strengths

• Data is linked to a specific, citable preprint (BioRxiv DOI: 10.1101/2024.04.12.589327)
• Experimental design includes biological replicates, with 2 independent samples per group
• Available under a permissive CC-BY-4.0 license for reuse

Limitations

• Column names and row counts are not provided, limiting immediate understanding of data structure
• Sample size is small, with each sample pooled from 2-3 zebrafish ventricles
• The associated manuscript is described as a preprint, not yet peer-reviewed

Provenance

Source

Manuel Fiegl

Collection Method

Bulk RNA sequencing of isolated zebrafish ventricles from controlled experiments.

Time Range

2024 (preprint publication year)

Freshness

Last updated on 2026-03-19

Geography

null