Bulk RNAseq of Th1, Th1/17, and Th17 Cells in Endometriosis Patients and Controls

Queen’s University doctoral research provides bulk RNA sequencing differential gene expression results from circulating Th1, Th1/17, and Th17 cell subsets. The dataset contains fold change values for comparisons between 10 endometriosis patients and 12 healthy controls, sequenced at the McGill Genome Centre using an Illumina NovaSeq X Plus 10B.

Use Cases

• Identify differentially expressed genes in Th17 cells based on fold change values mentioned in the description
• Compare transcriptional profiles between patient and control groups based on the described cell subsets
• Investigate immune remodeling in endometriosis based on the described aberrant Th17 cell phenotype

Strengths

• Data is associated with a doctoral thesis from Queen’s University, suggesting academic rigor
• Specifies the use of FACS sorting and Illumina NovaSeq X Plus 10B sequencing at the McGill Genome Centre
• Includes results from 10 endometriosis patients and 12 healthy controls

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download
• Column-level documentation is absent; field semantics must be inferred after download
• Data is under embargo, which may restrict immediate access or use

Provenance

Source

Borealis Harvested Dataverse, author Danielle Sisnett

Collection Method

Peripheral blood collection, PBMC isolation, FACS sorting, RNA isolation, and bulk RNA sequencing

Time Range

null

Freshness

Last updated 2026-04-25 04:11:45; freshness should be verified

Geography

null