Bushen Huatan Formula Effects on Non-Obese PCOS Rats via Exosomal miR-27a-3p

A 1.0 MB research dataset from figshare by Meng Chen, last updated in April 2026. It contains a study investigating the therapeutic effects of the Bushen Huatan Formula on non-obese polycystic ovary syndrome (PCOS) in rats. The research explores mechanisms involving adipose tissue-derived exosomal miR-27a-3p and PPARG signaling pathways.

Use Cases

• Analyze the relationship between exosomal miRNA expression and hormonal changes based on reported serum testosterone, E₂, and FSH levels.
• Investigate the correlation between metabolic markers and ovarian pathology based on data for fasting glucose, OGTT, and lipid profiles (TC, TG, HDL-C).
• Study signaling pathway alterations in PCOS based on quantified protein levels of PPARG, P-AKT, GLUT4, INSR, and IRS-1.
• Evaluate histological improvements based on described assessments of polycystic ovarian morphology and hepatic steatosis.

Strengths

• Includes specific quantitative results with p-values, such as AT-EXO-miR-27a-3p expression (5.13 ± 0.27 vs 17.91 ± 1.19).
• Study design details are provided, including a 35-day modeling period and a 28-day treatment period.
• Released under the permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred from the research paper after download.
• The dataset consists of supporting documents (PDF, DOCX); primary numerical data may require extraction.

Provenance

Source

figshare

Collection Method

Data generated from a controlled animal study inducing PCOS in rats via letrozole, a high-fat/high-sucrose diet, and a PEPD inhibitor.

Time Range

Experimental timeline spans a 35-day modeling period followed by a 28-day treatment period.

Freshness

Last updated 2026-04-09 11:16:12; freshness should be verified.

Geography

Laboratory study; specific geographic location is not stated.