Carboxypeptidase A6 CRISPR Screen Data for Bovine Enterovirus F Infection

A 1.4 GB dataset from a genome-wide CRISPR/Cas9 loss-of-function screen in Madin-Darby bovine kidney cells, identifying host factors for Bovine Enterovirus F. The data, authored by yuanchen Geng and last updated on 2026-04-20, supports findings linking carboxypeptidase A6 to viral production via the PI3K/AKT/FOXO1 signaling axis.

Use Cases

• Identifying host dependency factors for Bovine Enterovirus F based on CRISPR/Cas9 screening results.
• Analyzing the relationship between carboxypeptidase A6 expression and viral production metrics.
• Investigating the role of the PI3K/AKT/FOXO1 signaling axis in virus-induced apoptosis.
• Evaluating the antiviral potential of carboxypeptidase inhibition based on in vitro and in vivo experimental data.

Strengths

• Dataset size is 1.4 GB, indicating a substantial volume of experimental data.
• Includes results from in vitro and in vivo experiments, such as intestinal viral burden measurements (p < 0.0001).
• Licensed under CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Genome-wide CRISPR/Cas9 loss-of-function screen and subsequent virological and biochemical assays.

Time Range

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Freshness

Last updated 2026-04-20 03:00:38; freshness should be verified.

Geography

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