Carcinogenic Potency Database of 6,153 Bioassays

The Carcinogenic Potency Database (CPDB) contains results from 6,153 chronic carcinogenesis bioassays conducted over 45 years. It includes quantitative data on tumor incidence, dose-response, and statistical significance, alongside experimental details like strain, sex, route of administration, and target organ. The database is a standardized resource compiled from the general literature and NCI/NTP technical reports.

Use Cases

• Analyze tumor incidence and dose-response curve shapes across different routes of compound administration.
• Model carcinogenic potency based on quantitative data like statistical significance and duration of dosing.
• Investigate correlations between target organ, histopathology findings, and author-reported carcinogenicity opinions.
• Compare experimental outcomes across variables such as animal strain, sex, and length of experiment.

Strengths

• Contains data from 6,153 distinct long-term carcinogenesis experiments.
• Integrates 45 years of bioassay results into a single standardized resource.
• Includes both qualitative experimental details and quantitative statistical and dose-response data.

Limitations

• The dataset is no longer updated with new content, limiting contemporary relevance.
• Experiments vary widely in design and reporting standards, complicating direct comparisons.
• Specific column definitions and data structure are not detailed in the provided input.

Provenance

Source

U.S. Department of Health & Human Services, from general literature and NCI/NTP Technical Reports.

Collection Method

Compilation and standardization of results from published chronic carcinogenesis bioassays.

Time Range

45 years of experimental results (specific start and end years not provided).

Freshness

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Geography

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