Encompassing expression data for cathepsin D (CTSD) and cathepsin G (CTSG) from 58 human fracture hematoma samples collected 0-19 days post-trauma and from neutrophils polarized into N0, N1, and N2 phenotypes from five human donors. It was created by Lu, Fangzhou to investigate the association of these cathepsins with fracture healing phases and specific neutrophil phenotypes. The data shows CTSD expression increased over healing time, while CTSG remained constant, and differential expression between N1 and N2 neutrophil phenotypes.
Use Cases
- Analyze the correlation between CTSD expression levels and time post-trauma (0-19 days) in 58 fracture hematoma samples.
- Compare CTSG expression in N1 (pro-inflammatory) versus N2 (regenerative) neutrophil phenotypes from five human donors.
- Investigate the relationship between patient characteristics and the expression dynamics of CTSD and CTSG during the fracture healing cascade.
- Model the shift from inflammation to regeneration by analyzing the N2/N1 phenotype ratio in relation to CTSD and CTSG expression over time.
Strengths
- Includes 58 human fracture hematoma samples with a defined temporal range of 0-19 days post-trauma.
- Provides data from neutrophils polarized into distinct N0, N1, and N2 phenotypes from five human donors.
- Links molecular expression (CTSD, CTSG) to specific biological phases (fracture healing) and cell phenotypes (N1, N2).
Limitations
- Sample size for neutrophil phenotype analysis is limited to five donors, which may limit statistical power.
- The fracture hematoma time series (0-19 days) captures only the early phases of healing, not the complete process.
- Data is derived from a single study, requiring external validation for broader conclusions.
Provenance
- Source
- DataverseNL Harvested Dataverse
- Collection Method
- Human samples were harvested from fracture hematoma; neutrophils were harvested from donors and polarized in vitro. Expression was analyzed via bioinformatics and laboratory assays.
- Time Range
- Samples collected 0-19 days post-trauma.
- Freshness
- null
- Geography
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