Gut Microbiota and CSF Metabolites Causal Links to Schizophrenia

Yang Yang's Mendelian randomization study analyzes causal links between gut microbiota, cerebrospinal fluid metabolites, and schizophrenia. The dataset includes results from bidirectional two-sample MR analysis, multivariable MR, and MR Bayesian model averaging, identifying 20 risk-associated taxa and 8 protective taxa. The data was last updated on April 20, 2026.

Use Cases

• Validate causal pathways between gut microbiota and schizophrenia based on Mendelian randomization results.
• Analyze mediation effects of cerebrospinal fluid metabolites on schizophrenia risk using identified pathways.
• Prioritize key microbial taxa for further investigation based on multivariable MR and MR Bayesian model averaging results.
• Perform enrichment analysis on biosynthesis pathways of phenylalanine, tyrosine, and tryptophan based on the findings.

Strengths

• Includes results from multiple statistical methods: inverse-variance weighted, sensitivity analyses, reverse MR, and Steiger's directional test.
• Identifies 23 specific 'gut microbiota-CSF metabolites-schizophrenia' mediation pathways.
• No potential pleiotropy, heterogeneity, or reverse causality was detected, suggesting robust causal inference.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Blood metabolite replication yielded no positive results, limiting validation scope.

Provenance

Source

figshare

Collection Method

Instrumental variables selected from publicly available genome-wide association study datasets.

Freshness

Last updated 2026-04-20 18:21:42; freshness should be verified.