CD1d Knockout Swine Response to African Swine Fever Virus Genotype II

Daniel Madden's dataset from 2026 compares African swine fever virus infection in CD1D knockout and wildtype piglets. It includes data on viral DNA levels, disease severity, and pathological changes across blood and tissue samples. The work demonstrates that porcine CD1d is not critical for genotype II ASFV replication and virulence in vivo.

Use Cases

• Compare viral replication levels based on viral DNA data in blood and tissues.
• Analyze disease severity and mortality outcomes between knockout and wildtype groups.
• Study pathological changes such as fibrinous polyserositis and haemorrhagic lymphadenopathy.
• Evaluate the role of the CD1d glycoprotein in ASFV cellular tropism and pathogenesis.

Strengths

• Dataset includes experimental results from a CRISPR-Cas9 generated CD1D knockout swine model.
• Data covers multiple metrics: viral DNA levels, disease severity, mortality, and pathological examination.
• Files are provided in PNG and XLSX formats, supporting both visual and tabular analysis.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Experimental data from challenging CD1D knockout piglets with the virulent ASFV isolate MNG19.

Freshness

Last updated 2026-05-08 12:20:04; freshness should be verified.