CD4-CD8-T Cell Reconstitution and Survival After Pediatric HSCT

Xiaoling Wang's dataset contains clinical and immunological data from a cohort of 116 pediatric patients who underwent hematopoietic stem cell transplantation (HSCT). It examines the combined impact of acute graft-versus-host disease (aGVHD) and cytomegalovirus (CMV) infection on survival, with a focus on the role of CD4−CD8−T cell reconstitution as a potential prognostic biomarker. The analysis includes Kaplan-Meier survival curves, logistic regression, and Cox proportional hazards models.

Use Cases

• Prognostic modeling for post-HSCT survival based on lymphocyte subset levels
• Identifying risk factors for the co-occurrence of aGVHD and CMV infection
• Evaluating CD4−CD8−T cell count as a biomarker to mitigate adverse outcomes

Strengths

• Includes data from a defined cohort of 116 pediatric patients, providing a specific study population
• Analyses are detailed, including Kaplan-Meier, logistic regression, and Cox models
• Dataset is available under a permissive CC-BY-4.0 license for reuse

Limitations

• Column names and a precise row count are not provided, limiting understanding of the data structure
• The listed update date (2026-03-21) is in the future, creating a conflict in metadata reliability

Provenance

Source

Xiaoling Wang

Collection Method

Clinical cohort study of 116 pediatric HSCT patients, likely from a single institution.

Time Range

Observations include immune reconstitution data at day 90 post-HSCT.

Freshness

Last updated is listed as 2026-03-21, but this date is in the future.

Geography

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