CD8 Melanoma TILs TCR Repertoires from Metastasized Lymph Nodes

T-cell receptor (TCR) repertoire data from sorted CD8+ tumor-infiltrating lymphocytes (TILs) derived from metastasized lymph nodes of melanoma patients. The dataset compares CD39 PD-1 double-positive (DP) and not double-positive (nDP) TIL populations. Mikhail Goncharov published the dataset on figshare under a CC-BY-4.0 license, with a last update in May 2026.

Use Cases

• Analyzing TCR repertoire diversity and clonality based on TIL phenotype (DP vs nDP).
• Identifying tumor-associated T-cell clones based on sequence data from metastasized lymph nodes.
• Comparing immune signatures between CD39+ PD-1+ and other CD8+ TIL subsets in melanoma.
• Training models for predicting T-cell specificity or tumor reactivity from TCR sequences.

Strengths

• Data is focused on a specific and clinically relevant TIL phenotype (CD39 PD-1 DP).
• The 68.4 MB file size suggests a substantial amount of sequence data.
• The dataset is openly available under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely derived from sequencing sorted CD8+ TILs from patient lymph node samples.

Freshness

Last updated 2026-05-26 18:44:42; freshness should be verified.