CDC42-PAK4 Interaction: Structural Data on Kinase-GTPase Binding

Biochemical and structural data from Yale University probing the interaction between the RHO GTPase CDC42 and the serine/threonine kinase PAK4. The dataset likely contains results from solution scattering and X-ray crystallography experiments. It reveals an extended binding interface beyond the canonical CRIB domain, influencing kinase activity.

Use Cases

• Modeling protein-protein interaction interfaces based on the described extended binding contacts.
• Studying kinase activity modulation based on the described influence of CDC42 binding.
• Analyzing RHO GTPase effector mechanisms based on the described PAK4 interaction.

Strengths

• Data originates from a peer-reviewed scientific study published on paperswithcode.
• Analysis includes multiple experimental techniques: solution scattering and X-ray crystallography.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• License is marked as closed, restricting reuse.

Provenance

Source

Yale University

Collection Method

Experimental data from solution scattering and X-ray crystallography.