3D Bubbly Vertex Model Data for Cell Bulging and Extrusion in Curved Epithelia

A three-dimensional bubbly vertex model introduces a cellular bulging instability at topological defects, which is stronger than in standard vertex models. The dataset, authored by Oliver M. Drozdowski and harvested by heiDATA, was last updated on April 21, 2026. It is used to study the interplay between cell extrusion and curvature in epithelial tissues, with analysis informed by three-dimensional imaging data of spherical mouse colon organoids.

Use Cases

• Modeling cell shape instability at topological defects based on the described three-dimensional bubbly vertex model.
• Studying the interplay between epithelial curvature and cell extrusion mechanisms as described in the theory.
• Analyzing the effect of basal interfacial tension on cell shape control, as inferred from pentagonal cells in organoid imaging data.
• Comparing tissue-scale mechanisms like lumen pressure and spontaneous curvature against cellular-scale tension for stabilizing epithelial sheets.

Strengths

• Dataset is based on a novel three-dimensional bubbly vertex model for studying curved epithelial sheets.
• Analysis is informed by three-dimensional imaging data of spherical mouse colon organoids, providing a biological reference point.
• Last updated on 2026-04-21, indicating recent maintenance.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

heiDATA Harvested Dataverse

Collection Method

Likely contains simulation data from a three-dimensional bubbly vertex model, potentially accompanied by analysis of organoid imaging data.

Freshness

Last updated 2026-04-21 14:49:01; freshness should be verified.