Brazilin-Induced Cell Death in Breast Cancer Cell Lines

Flavonoid compounds brazilin and its acetylated derivative significantly reduced cell viability and proliferation in triple-negative MDA-MB-231 breast cancer cells. The dataset likely contains results from cell viability assays, oxidative stress measurements, mitochondrial integrity tests, and transcriptomic RNA sequencing analysis. Miriam Zuñiga-Eulogio published this 1.1 MB Excel file on figshare in April 2026.

Use Cases

• Compare drug efficacy based on cell viability and proliferation results across MDA-MB-231, MCF7, and MCF10A cell lines.
• Analyze transcriptomic changes induced by treatment based on RNA sequencing data mentioned in the description.
• Investigate apoptotic features based on confocal microscopy, Western blot, and RT-qPCR results.
• Evaluate mitochondrial stress and endoplasmic reticulum stress pathways based on the described biological effects.

Strengths

• Data includes results from multiple experimental methods: cell viability, oxidative stress, mitochondrial integrity, confocal microscopy, Western blot, RT-qPCR, and RNA sequencing.
• Compares effects across three distinct cell lines: triple-negative MDA-MB-231, luminal A MCF7, and nontumorigenic MCF10A.
• File is available in a standard, accessible format (XLSX) with a size of 1.1 MB.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Experimental laboratory research evaluating proapoptotic activity of compounds.

Freshness

Last updated 2026-04-10 11:06:03; freshness should be verified.