Chaetoglobosin Alkaloids: Fungicidal Activity Against Botrytis Cinerea

Twenty-four chaetoglobosin alkaloids, including nine unreported compounds, were isolated from the endophytic fungus Chaetomium sp. UJN-EF006. Their fungicidal activities against the agricultural pathogens Botrytis cinerea and Sclerotinia sclerotiorum were evaluated, with alkaloid 19 showing potent effects. The dataset, authored by Yinyin Wang and last updated on 2026-05-08, includes structural data in CIF format.

Use Cases

• Identify novel fungicidal compounds based on the reported chaetoglobosin alkaloids.
• Compare antifungal efficacy against Botrytis cinerea based on the reported EC50 values.
• Study structure-activity relationships for alkaloids based on the spectroscopic analyses.
• Investigate mechanisms of fungal inhibition based on the described cellular damage and oxidative stress.
• Assess phytotoxicity of potential fungicides based on the Arabidopsis thaliana germination assay.

Strengths

• Contains data on 24 distinct chaetoglobosin alkaloids, including 9 previously unreported compounds.
• Includes quantitative efficacy data (EC50 values) for a key alkaloid against two pathogens.
• Provides mechanistic insights from in vivo assays on tomato fruits and seedlings.
• File size is 1.4 MB, indicating a focused and likely well-defined dataset.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect the specific experimental bias inherent to the single-source study.

Provenance

Source

figshare

Collection Method

Chemical isolation and spectroscopic analysis from an endophytic fungus, followed by biological assays.

Time Range

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Freshness

Last updated 2026-05-08 18:03:32; freshness should be verified.

Geography

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