Chaetoglobosin Alkaloids with Fungicidal Activity Against Botrytis cinerea

Nine unreported and 15 known chaetoglobosin alkaloids were separated from the endophytic Chaetomium sp. UJN-EF006. Their fungicidal activities against the agricultural pathogens Botrytis cinerea and Sclerotinia sclerotiorum were evaluated, with alkaloid 19 showing potent antifungal effects. The dataset, authored by Yinyin Wang, was last updated on 2026-05-08.

Use Cases

• Identifying promising fungicidal agents based on reported EC50 values against Botrytis cinerea and Sclerotinia sclerotiorum.
• Comparing the efficacy of novel alkaloids to commercial fungicides like azoxystrobin and carbendazim.
• Studying the mechanism of action of chaetoglobosin alkaloids based on described morphological and cellular effects.
• Assessing phytotoxicity of potential fungicides using germination and shoot growth assays on Arabidopsis thaliana.

Strengths

• Includes 24 chaetoglobosin alkaloids, with 9 being unreported compounds.
• Provides specific EC50 values (0.80 and 1.47 μg/mL) for the most potent alkaloid against two pathogens.
• Contains results from in vivo assays on tomato fruits and seedlings demonstrating practical efficacy.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (565.3 KB), indicating a limited scope of data.

Provenance

Source

figshare

Collection Method

Compounds were separated from an endophytic fungus and their structures determined by spectroscopic analyses.

Time Range

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Freshness

Last updated 2026-05-08 18:03:33; freshness should be verified.

Geography

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