Mouse Ocular Proteomics from a 35-Day Spaceflight Mission

Proteomic data from a 2017 NASA study investigating ocular changes in mice after a 35-day mission on the International Space Station. The dataset captures protein expression profiles related to cell death, immune response, and metabolic stress in ocular tissue, comparing flight mice to ground controls. Analysis indicated significant blood-retinal barrier disruption and altered intraocular pressure post-flight.

Use Cases

• Identify protein biomarkers for spaceflight-induced ocular stress based on altered expression profiles.
• Model pathways of blood-retinal barrier disruption based on changes in tight junction proteins like ZO-1.
• Analyze correlations between intraocular pressure changes and proteomic signatures in microgravity.
• Investigate mitochondrial and metabolic stress responses in retinal tissue from spaceflight exposure.

Strengths

• Data originates from a controlled NASA experiment with ground and vivarium control groups.
• Includes specific physiological measurements, such as intraocular pressure ranges (14.4-20.3 mmHg) and statistical significance (p < 0.05).
• Proteomic analysis covers multiple key pathways: cell death, immune response, mitochondrial function, and metabolic stress.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• File formats include BIN and HTML, which may require specialized tools for access and analysis.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Experimental data from mice launched to the ISS on Space-X 12 in August 2017, with tissues collected within 38 +/- 4 hours of return.

Time Range

2017

Freshness

Last updated 2026-03-13 20:03:41.758186; freshness should be verified.

Geography

International Space Station and Kennedy Space Center.