RR-9 Mission: Mouse Ocular Pressure and Retinal Protein Changes After 35-Day Spaceflight

NASA collected this dataset to characterize ocular effects of spaceflight on mice. It includes repeated intraocular pressure measurements from before and after a 35-day mission on the International Space Station in 2017, alongside proteomic and immunohistochemical analysis of retinal tissue. Results indicate significant changes in pressure, apoptosis, and protein expression related to blood-retinal barrier integrity.

Use Cases

• Modeling the relationship between spaceflight duration and intraocular pressure changes based on pre- and post-flight measurements.
• Identifying protein expression pathways altered by microgravity based on proteomic analysis results.
• Investigating blood-retinal barrier integrity markers like AQP-4, PECAM-1, and ZO-1 from immunohistochemical data.
• Comparing cellular apoptosis levels in retinal tissue between flight and control groups.

Strengths

• Includes specific intraocular pressure ranges (14.4–19.3 mmHg vs 16.3–20.3 mmHg) with statistical significance (p < 0.05) reported.
• Data originates from a controlled NASA spaceflight experiment with ground and vivarium control groups.
• Analysis covers multiple biological levels: physiological pressure, cellular apoptosis, and proteomic pathways.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is stored in a BIN format, which may require specialized tools for access and interpretation.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Experimental data from mice launched to the ISS on Space-X 12 in August 2017, with tissues collected post-splashdown for analysis.

Time Range

2017 (flight mission and data collection).

Freshness

Last updated 2026-03-13 19:52:38.666931; freshness should be verified.

Geography

International Space Station and Kennedy Space Center.