Mouse Ocular Responses to a 35-Day Spaceflight Mission: Microscopy Data

Microscopy assay data from a study characterizing the effects of a 35-day spaceflight mission on mouse ocular tissue. The dataset was generated by the National Aeronautics and Space Administration (NASA) from mice launched to the International Space Station in August 2017. It includes results from immunohistochemical and proteomic analyses to investigate blood-retinal barrier disruption and retinal adaptations.

Use Cases

• Analyzing changes in protein expression profiles (e.g., AQP-4, PECAM-1, ZO-1) in ocular tissue after spaceflight.
• Investigating apoptosis levels in retinal and vascular endothelial cells between flight and control groups.
• Modeling the relationship between intraocular pressure measurements taken pre-flight and post-flight.
• Studying alterations in biological pathways related to cell death, immune response, and mitochondrial function from proteomic data.

Strengths

• Data originates from a controlled NASA spaceflight experiment with specific ground and vivarium control groups.
• Includes specific, statistically significant findings reported in the description, such as intraocular pressure ranges (14.4–19.3 mmHg vs 16.3–20.3 mmHg) and p-values (p < 0.05).
• Assays combine multiple analysis methods: intraocular pressure measurement, immunohistochemistry, and proteomics.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is stored in a BIN format, which may require specialized tools for access and analysis.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Molecular Cellular Imaging (Microscopy) assay of ocular tissues from C57BL/6 mice after a 35-day spaceflight mission.

Time Range

Experimental launch and data collection occurred in August 2017.

Freshness

Last updated 2026-03-13 19:57:16.277627; freshness should be verified.

Geography

Mice were launched from Kennedy Space Center and housed on the International Space Station.