SERCA Function in Mouse Muscles After 35-37 Days of Spaceflight

Experimental results characterize the sarco(endo)plasmic reticulum calcium ATPase (SERCA) pump function in murine skeletal muscles following a 35-37 day spaceflight mission. The dataset derives from calcium uptake spectrofluorometry and Western blot assays conducted on soleus and tibialis anterior muscles from male and female mice. It was published by the National Aeronautics and Space Administration and last updated in March 2026.

Use Cases

• Modeling the differential impact of spaceflight on muscle fiber types based on the described soleus vs. tibialis anterior results.
• Analyzing the relationship between reactive oxygen/nitrogen species (RONS) protein adduction and calcium uptake dysfunction described in the soleus data.
• Investigating correlations between SERCA protein content and functional pump activity as reported for different muscles.
• Studying sex-specific responses to microgravity using the male and female muscle samples mentioned.

Strengths

• Focuses on a specific, controlled experimental duration of 35-37 days of spaceflight.
• Includes comparative data from two distinct muscle types (soleus and tibialis anterior) and both male and female subjects.
• Combines functional calcium uptake assays with protein content analysis via Western blot.

Limitations

• Row count and dataset scale are unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is stored in a BIN file format, which may require specialized tools for access and interpretation.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Data from calcium uptake (spectrofluorometry) and Western blot assays on mouse muscle tissue.

Time Range

Experimental period covers 35-37 days of spaceflight.

Freshness

Last updated 2026-03-13 19:53:01.878181

Geography

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