Chemical Synthesis Data for Novel PD-L1 Degradation Agent

685 bytes of CSV data from a 2026 study details the synthesis and screening of nitidine derivatives for cancer immunotherapy. Author Qun Wang describes a one-pot method using visible light catalysis to produce phenanthridine compounds, with activity screening identifying derivative e24 as a potent PD-L1 degradation agent targeting CSN5. The dataset supports the reported antitumor effects observed in Lewis tumor and MC38 mouse models.

Use Cases

• Analyze the chemical synthesis pathway described for creating functionalized phenanthridines from aldehydes using pyrrolidine and photocatalysts.
• Compare the activity screening results between derivative e24, prototype nitidine, and positive control JQ-1 on PD-L1 expression reduction.
• Model the biological mechanism where compound e24 targets the CSN5 regulatory factor to induce PD-L1 degradation.
• Investigate the reported enhancement of tumor-infiltrating T-cell immunity and inhibition of MDSCs and Tregs from the mouse model data.

Strengths

• Data is very recent, last updated in March 2026.
• Describes a specific and novel biological mechanism (targeting CSN5 for PD-L1 degradation).
• Includes results from two in vivo mouse models (Lewis tumor and MC38).

Limitations

• Extremely small data volume at only 685 bytes, indicating minimal structured data.
• No column names or sample data are provided, limiting immediate analytical utility.
• The dataset appears to be a summary or description rather than a tabular dataset with rows and features.

Provenance

Source

figshare

Collection Method

One-pot chemical synthesis and subsequent biological activity screening.

Time Range

null

Freshness

2026-03-13

Geography

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