Mycobacterium abscessus β-Lactam Targets Across Subspecies and Growth States

A chemoproteomic dataset from Kaylyn L. Devlin, last updated April 17, 2026, identifies enzymes targeted by β-lactam antibiotics in Mycobacterium abscessus. It compares targets across two subspecies in both replicating and nonreplicating cultures, listing 17 consistently active targets, including seven previously unknown binders.

Use Cases

• Identify potential β-lactam drug targets based on the comprehensive list of Mab enzymes reported.
• Compare antibiotic target profiles across different Mycobacterium abscessus subspecies.
• Analyze target engagement differences between actively replicating and nonreplicating (persistent) bacterial cultures.
• Evaluate β-lactam inhibition profiles for specific Mab enzymes, such as comparing imipenem and cefoxitin efficacy.

Strengths

• Identifies 17 β-lactam targets active in every tested condition.
• Includes seven previously unknown β-lactam-binding enzymes.
• Compares targets across two Mab subspecies and two distinct culture states (replicating and nonreplicating).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect experimental bias inherent to the specific chemoproteomic methodology.

Provenance

Source

Kaylyn L. Devlin via figshare

Collection Method

Generated using β-lactam-derived activity-based probes and chemoproteomics.

Freshness

Last updated 2026-04-17 20:30:02