Chromosomal abnormalities and pregnancy outcomes in 350 pregnancies with prenatally diagno

Resat Misirlioglu's retrospective cohort study comprises 350 singleton pregnancies with a prenatal diagnosis of aberrant right subclavian artery (ARSA) from a tertiary perinatology center between January 2020 and April 2025. Cases are classified as isolated ARSA (n=200), ARSA with soft markers (n=80), or non-isolated ARSA (n=70). The dataset reports primary outcomes of chromosomal abnormalities and live-birth rates across these phenotypic groups.

Use Cases

• Assessing risk gradients for chromosomal abnormalities based on prenatal ARSA phenotype classification.
• Evaluating the diagnostic yield of invasive genetic testing in fetuses with isolated versus non-isolated ARSA.
• Investigating associations between conotruncal cardiac anomalies and 22q11.2 deletions in prenatal cohorts.
• Modeling predictors of adverse pregnancy outcomes using multivariable logistic regression on phenotypic features.

Strengths

• Dataset includes 350 well-defined prenatal cases with clear phenotypic classification.
• Primary outcomes are reported with explicit denominator separation for whole-cohort prevalence and diagnostic yield.
• 22q11.2 deletion case definition required dual confirmation by FISH and chromosomal microarray analysis.
• Multivariable logistic regression results are provided, including adjusted odds ratios and confidence intervals.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is from a single-center retrospective study, which may limit generalizability.

Provenance

Source

Resat Misirlioglu via figshare.

Collection Method

Retrospective single-center cohort study of prenatal diagnoses.

Time Range

January 2020 to April 2025.

Freshness

Last updated 2026-06-01 02:29:50; freshness should be verified.