Aged (15–18 months) male and female HIV-1 Tat transgenic mice were treated with chronic CBD (3 mg/kg, s.c., for 12 weeks). Behavioral tests assessed object recognition memory, anxiety-like behavior, spontaneous nociception, and locomotor activity. Liquid chromatography-tandem mass spectrometry and Western blotting measured endocannabinoid ligands, enzymes, and receptors across prefrontal cortex, amygdala, brainstem, and spinal cord.
Use Cases
- Analyze sex-dependent effects of chronic CBD on recognition memory based on behavioral battery results
- Model interactions between cannabinoid receptors and GPR55 expression based on Western blotting data
- Compare endocannabinoid ligand levels across CNS regions based on mass spectrometry measurements
- Evaluate the impact of chronic CBD on body temperature and mass modulation based on physiological data
Strengths
- Data includes both male and female subjects, allowing for sex-dependent analysis
- Chronic treatment duration of 12 weeks provides longitudinal insights
- Measurements cover four distinct CNS regions (prefrontal cortex, amygdala, brainstem, spinal cord)
- Behavioral battery assesses multiple neurobehavioral domains
Limitations
- Column-level documentation is absent; field semantics must be inferred after download
- Row count is unknown, which may limit suitability assessment
- Freshness should be verified as last updated date is 2026-06-01
Provenance
- Source
- ODUM Harvested Dataverse
- Collection Method
- Experimental study using behavioral tests, liquid chromatography-tandem mass spectrometry, and Western blotting.
- Freshness
- Last updated 2026-06-01 03:10:12