Cinnarizine and Meclizine: C. elegans Lifespan Study with Lab Replication

A 2026 study from the Caenorhabditis Intervention Testing Program (CITP) provides raw data and statistical outputs on the lifespan effects of mTOR inhibitors cinnarizine and meclizine on the N2 strain of C. elegans. The dataset includes results from multiple drug concentrations, with one concentration replicated across two independent laboratories. It comprises raw data, analysis outputs, and an R script in RTF and XLSX formats, totaling 631.6 KB.

Use Cases

• Replicate lifespan analysis based on raw survival data for C. elegans.
• Compare drug efficacy across multiple concentrations of cinnarizine and meclizine.
• Assess experimental reproducibility using the inter-lab replication data.
• Perform secondary statistical analysis using the provided R script and outputs.

Strengths

• Includes raw data, processed statistical outputs, and an analysis script (R), facilitating reproducibility.
• Features experimental replication for one drug concentration across two labs, allowing assessment of result robustness.
• Released under a permissive CC-BY-4.0 license, enabling broad reuse.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• The dataset is small (631.6 KB), indicating a limited scope and sample size.

Provenance

Source

Caenorhabditis Intervention Testing Program (CITP)

Collection Method

Experimental study treating C. elegans N2 with drugs and measuring lifespan.

Freshness

Last updated 2026-05-07 22:15:50.