Clinical Association of Serum miR-524-5p with TBI Severity and 28-Day Outcomes

A 2026 study by Xianfeng Yu on figshare investigates miR-524-5p as a biomarker for traumatic brain injury. The dataset includes measurements from 150 TBI patients and 45 controls, linking serum miRNA levels to injury severity and 28-day prognostic outcomes. It also contains results from in vitro experiments on BV2 microglia cells.

Use Cases

• Developing diagnostic classifiers for TBI subtypes based on serum miR-524-5p levels mentioned in the description
• Building prognostic models for 28-day mortality in severe TBI patients using miRNA expression
• Studying the role of miR-524-5p in regulating microglia-mediated neuroinflammation and oxidative stress
• Correlating biomarker levels with clinical injury severity scores (GCS) as indicated in the study

Strengths

• Includes data from a defined cohort of 150 TBI patients and 45 controls
• Links biomarker levels to concrete clinical outcomes over a 28-day period
• Combines human clinical data with in vitro cellular experiment results

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment
• The 3.8 MB size suggests a small dataset, potentially limiting statistical power for some analyses

Provenance

Source

figshare, author Xianfeng Yu

Collection Method

Clinical study recruiting patients and controls, with serum quantification and in vitro cell experiments

Time Range

Study published in 2026; specific data collection period is not stated

Freshness

Last updated 2026-04-24 16:09:00; freshness should be verified

Geography

Geographic coverage of the patient cohort is not specified