Depression Clinical Trials from EU and US Registries with Genetic Sample Indicators

A database of depression-related clinical trials developed in collaboration with Medicines Discovery Catapult. It integrates structured and unstructured data from the US ClinicalTrials.gov and EU Clinical Trials Register, covering interventions, sample sizes, trial phases, and participant demographics. The collection includes a semantic similarity score to identify trials likely to contain biological samples like blood or DNA.

Use Cases

• Identifying clinical trials with available biological samples based on the semantic similarity scoring method described.
• Analyzing trial characteristics like phase, status, and sponsor across EU and US registries.
• Studying trends in depression intervention types and participant demographics over time.

Strengths

• Integrated data from two major clinical trial registries (US and EU).
• Includes a novel semantic similarity score to flag trials likely containing genetic information.
• Released under a permissive CC-BY-4.0 license.
• Contains multiple file formats (PDF, XLSX, CSV, etc.) totaling 38.1 MB.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect geographic or registry-specific bias inherent to the source platforms.

Provenance

Source

Medicines Discovery Catapult (MDC), US ClinicalTrials.gov (via AACT database), EU Clinical Trials Register.

Collection Method

Systematic extraction of structured and unstructured data from registry records and publications, enhanced with a vector-based NLP semantic similarity approach.

Freshness

Last updated 2026-04-27 11:38:50; freshness should be verified.

Geography

European Union and United States