ClinVar Missense Variants with High Review Scores

ClinVar-missense34 contains 4,547 rows of genetic variant data, each with 50 columns. The dataset focuses exclusively on missense mutations that have received high-quality review scores of 3 or 4 from the ClinVar database.

Use Cases

• Predict variant pathogenicity using the 50 available features for each missense mutation
• Analyze the distribution of high-confidence (review scores 3 and 4) missense variants across the dataset
• Train a classifier to identify patterns among the 4,547 curated missense records

Strengths

• Dataset is focused on 4,547 high-confidence missense variants with review scores of 3 or 4
• Provides 50 columns of features for each genetic variant record
• Data is curated from the authoritative ClinVar database for clinical genetics

Limitations

• Small sample size of 4,547 rows may limit statistical power for some analyses
• Scope is restricted to missense variants only, excluding other mutation types
• Lacks metadata such as column descriptions, making feature interpretation difficult

Provenance

Source

ClinVar database

Collection Method

Curated extraction of missense variants with specific review scores