Co-Crystal Structures of USP5 Zf-UBD with Weakly Binding Compounds

Co-crystal structures of the USP5 zinc finger ubiquitin binding domain (Zf-UBD) with compounds identified by 19F NMR and SPR assays. The data was generated by Mandeep Mann at the University of Toronto to determine crystallization conditions and visualize ligand electron density in the protein's binding pocket. The dataset's row count and specific file formats are unknown.

Use Cases

• Analyzing protein-ligand binding modes based on solved co-crystal structures.
• Validating weak binding hits from 19F NMR and SPR assays with structural data.
• Studying crystallization conditions for the USP5 Zf-UBD domain.
• Investigating electron density visibility for ligands in a protein binding pocket.

Strengths

• Data originates from a specific research project at the University of Toronto.
• Structures are derived from well-diffracting co-crystals, suggesting high-quality crystallographic data.
• Ligands were pre-validated by 19F NMR and SPR binding assays.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

Mandeep Mann, University of Toronto

Collection Method

X-ray crystallography of co-crystals grown from compounds identified by 19F NMR and SPR assays.