Patricia Soto Bielicka's dataset evaluates the combined toxicological impact of polystyrene nanoparticles and the flame retardant TBBPA. The data was generated from two Spanish Research Agency-funded projects, RTI2018-096046-B-C22 and PID2022-141894OB-C22, using differentiated Caco-2 cells and Caco-2/HT29-MTX co-cultures. It focuses on genotoxicity and disruption of intestinal barrier integrity and function.
Use Cases
- Modeling intestinal barrier disruption based on co-exposure to nanoparticles and flame retardants.
- Assessing genotoxicity endpoints from in vitro cellular assays described in the study.
- Comparing toxicological effects between differentiated Caco-2 cells and Caco-2/HT29-MTX co-culture models.
- Investigating the role of flame retardants as contaminants transported by nano/microplastics.
Strengths
- Data originates from two specific, funded research projects with grant codes RTI2018-096046-B-C22 and PID2022-141894OB-C22.
- Uses validated in vitro models (differentiated Caco-2 cells and Caco-2/HT29-MTX co-cultures) for human intestinal barrier studies.
- Focuses on a specific, contemporary environmental health issue: co-exposure to nanoparticles and flame retardants.
Limitations
- Column-level documentation is absent; field semantics must be inferred after download.
- Row count is unknown, which may limit suitability assessment.
- Description metadata is limited; actual data quality requires manual inspection after download.
Provenance
- Source
- Patricia Soto Bielicka, e-cienciaDatos Harvested Dataverse
- Collection Method
- Generated from in vitro assays on human intestinal cellular models.
- Time Range
- null
- Freshness
- Last updated 2026-04 21 17:42:14; freshness should be verified.
- Geography
- null