Cohort Frequencies for Autosomal SNPs in 180 Continental Africans

Cohort-wide frequencies for all autosomal single-nucleotide polymorphisms (SNPs) first presented in the paper by Fan et al. (2023). The data is a 105.0 MB tab-delimited file with variant positions in GRCh37 coordinates, uploaded to figshare by Matthew Hansen. It was last updated on 2026-04-18.

Use Cases

• Analyzing allele frequency distributions across African populations based on the AF (alternative allele frequency) column.
• Studying population structure and demographic history based on genome-wide SNP data.
• Identifying signatures of local adaptation using variant positions (CHROM, POS) and allele frequencies.
• Benchmarking variant calling pipelines against a dataset from a published whole-genome sequencing study.

Strengths

• Data is directly linked to a peer-reviewed publication in Cell (PMID:36868214).
• File size of 105.0 MB suggests a substantial number of genomic variants.
• Column definitions for CHROM, POS, REF, ALT, and AF are explicitly provided in the description.

Limitations

• Row count is unknown, which may limit suitability assessment for specific analyses.
• The description does not specify the number of distinct populations or sampling details within the 180 individuals.
• Data is provided in GRCh37 coordinates, which is an older human genome reference assembly.

Provenance

Source

Data originates from the whole-genome sequencing study 'Whole-genome sequencing reveals a complex African population demographic history and signatures of local adaptation' (Fan et al., 2023).

Collection Method

Likely derived from whole-genome sequencing data of 180 individuals, as referenced in the associated paper.

Freshness

Last updated 2026-04-18 21:01:55.

Geography

Samples are from continental African populations, though specific countries or regions are not detailed in the provided input.