Benzodiazepine Protein Target Data from Rat Brain Synaptosomes

2026 data from chemoproteomic affinity-based protein profiling (AfBPP) experiments on rat brain synaptosomes using synthesized benzodiazepine probes. The dataset, provided in XLSX format, supports the identification of specific benzodiazepine drug targets, including GABA_A receptor subunits and other ion channel proteins, through combined quantitative and qualitative statistical analyses.

Use Cases

• Apply chemoprotR package analyses to presence–absence data for target identification in AfBPP datasets.
• Compare protein targets identified by different benzodiazepine affinity-based probes (AfBPs) like FR-DA and flunitrazepam-based probes.
• Analyze competitive labeling results using flurazepam to identify specific binding sites from the probe data.
• Investigate overlap or uniqueness of significant protein targets across the three tested benzodiazepine probes.

Strengths

• Data generated from controlled chemoproteomic experiments on rat brain synaptosomes.
• Includes results from three distinct synthesized benzodiazepine affinity-based probes (AfBPs).
• Demonstrates a combined statistical analysis method for interpreting presence–absence data in AfBPP.

Limitations

• Dataset is small at 2.5 MB, indicating limited scope or sample depth.
• Specific row count and column structure are unknown, complicating initial assessment of data volume and features.
• Data is specific to rat brain synaptosomes and benzodiazepine probes, limiting generalizability to other tissues or drug classes.

Provenance

Source

Lydia H. Griggs via figshare.

Collection Method

Affinity-based protein profiling (AfBPP) applied to rat brain synaptosomes using synthesized benzodiazepine affinity-based probes, with competitive labeling by flurazepam.

Time Range

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Freshness

Last updated March 2026.

Geography

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