Hofmeisterin I and Analogues: Antinociceptive Evaluation in Zebrafish and Mice

A 1.2 MB dataset published on figshare in April 2026 by Sebastián Martínez Flores. It contains results from the comparative antinociceptive evaluation of hofmeisterin I and its synthetic analogues, tested in zebrafish and murine formalin models. The dataset includes X-ray analyses (CIF files) of compounds 1 and 12.

Use Cases

• Compare the antinociceptive potency of halogenated versus acetylated derivatives based on zebrafish and mice model results.
• Investigate the safety profile of nitrogen-containing imide analogues based on toxicity and efficacy data.
• Study receptor involvement (TRPV1, CB2, PPARγ) and system modulation (opioid, serotonergic) based on mechanistic study findings.
• Analyze molecular structures based on the reported X-ray crystallographic information (CIF files).

Strengths

• Includes X-ray crystallographic data (CIF files) for two key compounds.
• Data is from a specific, recent publication (last updated April 2026).
• Compounds were tested in two distinct biological models (zebrafish and mice).

Limitations

• Row count and column-level documentation are unknown; field semantics must be inferred after download.
• The dataset is small (1.2 MB), which may limit the scope of analysis.
• Data may reflect the specific experimental bias inherent to the single study.

Provenance

Source

figshare

Collection Method

Experimental results from biological assays and X-ray crystallography.

Time Range

Publication date 2026.

Freshness

Last updated 2026-04-11 13:06:57

Geography

Research likely conducted in Central Mexico, given the plant's origin.