Hofmeisterin I and Analogues: Antinociceptive Activity in Zebrafish and Mice

Hofmeisterin I and its synthetic derivatives were evaluated for pain relief using zebrafish and murine formalin models. The dataset includes X-ray crystallographic information files (CIF) for compounds 1 and 12, published by Sebastián Martínez Flores in April 2026. A nitrogen-containing imide analogue (compound 12) showed improved efficacy and a safer profile, with mechanistic studies implicating TRPV1, CB2, and PPARγ receptors.

Use Cases

• Structure-activity relationship analysis based on the biological evaluation of hofmeisterin I and its halogenated and acetylated derivatives.
• Mechanistic study of antinociceptive pathways based on the reported involvement of TRPV1, CB2, and PPARγ receptors.
• Comparative efficacy and safety profiling based on the testing results in zebrafish and murine formalin models.
• Crystallographic analysis of novel compounds based on the provided X-ray data files for compounds 1 and 12.

Strengths

• Includes X-ray crystallographic data files (CIF format) for two key compounds.
• Biological evaluation spans two model organisms: zebrafish (Danio rerio) and mice.
• Published under a CC-BY-NC-4.0 license, allowing non-commercial reuse with attribution.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is small at 770.9 KB, indicating limited scope.
• Data may reflect the specific experimental and synthetic bias inherent to the single study.

Provenance

Source

figshare, authored by Sebastián Martínez Flores.

Collection Method

Data likely originates from laboratory synthesis, biological assays, and X-ray crystallography experiments.

Time Range

null

Freshness

Last updated 2026-04-11 13:06:56

Geography

Research is based on a medicinal plant (Hofmeisteria schaffneri) used in Central Mexico.