Hofmeisterin I and Analogues: Antinociceptive Activity in Zebrafish and Mice

Central Mexico medicinal plant Hofmeisteria schaffneri is the source of compounds tested for pain relief. The dataset includes results from antinociceptive evaluations of hofmeisterin I and its synthetic derivatives in zebrafish (Danio rerio) and murine formalin models, along with X-ray analyses. Sebastián Martínez Flores published the data on figshare in April 2026.

Use Cases

• Compare the antinociceptive potency of halogenated versus acetylated analogues based on the biological assessment results.
• Identify promising analgesic scaffolds based on the reported efficacy and safety profile of compound 12.
• Study receptor mechanism involvement based on the described TRPV1, CB2, and PPARγ receptor interactions.
• Analyze synthetic compound structures based on the reported X-ray analyses of compounds 1 and 12.

Strengths

• Includes data from two distinct biological models: zebrafish and mice.
• Contains X-ray structural analyses for key compounds 1 and 12.
• Mechanistic studies indicate involvement of specific receptors (TRPV1, CB2, PPARγ).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (885.9 KB), indicating a limited scope of experimental results.

Provenance

Source

figshare

Collection Method

Biological assessment of synthesized compounds in animal models.

Time Range

Experimental timeframe not specified.

Freshness

Last updated 2026-04-11 13:06:55; freshness should be verified.

Geography

Plant source and research context is Central Mexico.