Wound Healing in a Rat Chemical Burn Model Treated with Stem Cells and Exosomes

A 2026 study by Hamit Hakan Bekir compares the effects of human umbilical cord-derived mesenchymal stem cells (HucMSCs) and their exosomes on wound healing in 24 Wistar rats with alkaline-induced skin burns. The dataset includes results showing 78.15% wound closure for HucMSC-treated rats versus 57.35% for controls, with histopathological evaluations over 21 days. Supporting files are in PNG, JPG, and DOCX formats, totaling 4.4 MB.

Use Cases

• Compare wound closure rates based on the reported percentages for different treatment groups.
• Analyze histopathological changes such as inflammation and muscle regeneration over the 21-day timeline.
• Study neoangiogenesis effects, particularly the early-phase angiogenesis promoted by exosome treatment.
• Benchmark treatment efficacy in chemical burn models using the provided control group data.

Strengths

• Includes specific quantitative results: 78.15% wound closure for HucMSC group, 66.11% for Exo-HucMSC group, and 57.35% for control group.
• Provides histopathological evaluation over multiple time points (days 1, 3, 7, and 21) with statistical significance (p-values) reported.
• Dataset is openly licensed under CC-BY-4.0, facilitating reuse and sharing.

Limitations

• Row count and column-level documentation are absent; data structure must be inferred from the supporting files.
• The dataset is small (4.4 MB), which may limit the scope of analysis.
• Data may reflect bias inherent to the specific animal model (Wistar rats) and chemical burn induction method.

Provenance

Source

figshare

Collection Method

Experimental study involving 24 Wistar rats with induced chemical burns, randomly assigned to three treatment groups.

Time Range

Study timeline spans 21 days of observation post-burn induction.

Freshness

Last updated 2026-04-17 10:14:10; freshness should be verified.