Quetiapine Serum Concentration Data from 138 Patients for Method Comparison

138 psychiatric patient serum samples were analyzed for quetiapine concentration using two analytical methods: 2D-LC and LC-MS/MS with self-calibrated internal standard. The dataset includes results from a complete method validation, Bland–Altman analysis, and correlation studies, with linear ranges of 60.74–1518.48 ng/ml and 60.88–1522.02 ng/ml for the respective methods. The data was published by Mengli Ding on figshare under a CC-BY-4.0 license and last updated in May 2026.

Use Cases

• Validate analytical method agreement for drug quantification based on Bland–Altman and correlation analysis results.
• Benchmark 2D-LC performance against LC-MS/MS for therapeutic drug monitoring applications.
• Assess linearity and precision of clinical assays based on reported validation metrics.
• Support method selection for quetiapine monitoring in psychiatric patient serum.

Strengths

• Includes data from 138 patient samples, providing a clinical-scale comparison.
• Reports specific validation metrics: linear ranges, relative standard deviation <15%, and a Pearson correlation coefficient of 0.994.
• Employs established statistical methods (Bland–Altman, Passing–Bablok regression) for method comparison.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (30.6 KB), indicating limited scope, likely containing summary results rather than raw observations.

Provenance

Source

Mengli Ding via figshare

Collection Method

Serum samples from psychiatric patients were analyzed using 2D-LC and LC-MS/MS methods with full validation.

Time Range

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Freshness

Last updated 2026-05-14 08:06:53; freshness should be verified.

Geography

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