CNP7 Inhibitor Chemoproteomics Data for HMGCS1 in Cancer Cells

3.5 MB of chemoproteomic data from a study developing CNP7, a covalent inhibitor of HMG-CoA synthase 1 (HMGCS1). The dataset, authored by Liang Sun and shared on figshare under CC-BY-NC-4.0, was last updated on 2026-05-13. It includes target engagement ratios and off-target profiles generated using orthogonal chemoproteomic methods.

Use Cases

• Validate covalent inhibitor selectivity based on chemoproteomic target engagement ratios.
• Compare on- and off-target profiles of inhibitors using orthogonal chemoproteomic methods.
• Investigate cell line-specific anticancer activity patterns related to mevalonate pathway inhibition.
• Analyze protein deprenylation dynamics following HMGCS1 inhibition.
• Benchmark scavenging proteomics approaches against traditional enrichment proteomics.

Strengths

• Includes a 2.29 Å cryo-EM structure of the inhibitor bound to its target.
• Provides target engagement ratios across the proteome from a complementary scavenging proteomics approach.
• Data is structured in an XLSX file format, facilitating analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is relatively small at 3.5 MB, which may indicate limited scope.

Provenance

Source

figshare

Collection Method

Integrated orthogonal chemoproteomic methods, including scavenging proteomics.

Freshness

Last updated 2026-05-13 18:05:01; freshness should be verified.