CNP7: Selective HMGCS1 Inhibitor Chemoproteomics Data

A chemoproteomics dataset from figshare, authored by Liang Sun and last updated in May 2026. It contains data supporting the development and characterization of CNP7, a covalent inhibitor targeting HMG-CoA synthase 1 (HMGCS1) in cancer metabolism. The 4.8 MB dataset includes results from orthogonal chemoproteomic methods and a cryo-EM structure.

Use Cases

• Validate covalent inhibitor selectivity based on orthogonal chemoproteomic profiling described in the study
• Compare target engagement ratios across the proteome using the scavenging proteomics approach outlined
• Analyze cell line-specific anticancer activity patterns for HMGCS1 inhibitors versus statins
• Investigate protein deprenylation dynamics following HMGCS1 inhibition as described

Strengths

• Includes a 2.29 Å cryo-EM structure of the inhibitor bound to its target
• Integrates orthogonal chemoproteomic methods as described in the validation framework
• File size is 4.8 MB, indicating a focused dataset

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download

Provenance

Source

figshare

Collection Method

Integrating orthogonal chemoproteomic methods, including scavenging proteomics, for covalent inhibitor characterization.

Freshness

Last updated 2026-05-13 18:04:54; freshness should be verified