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Description
A chemoproteomics dataset from figshare, authored by Liang Sun and last updated in May 2026, presents target engagement profiles for covalent inhibitors. The 2.0 MB XLSX file contains data generated through orthogonal chemoproteomic methods, including scavenging proteomics, to analyze on- and off-target activity. It specifically details the selectivity of CNP7, a cyanopyrrolidine inhibitor of HMG-CoA synthase 1 (HMGCS1), supported by a 2.29 Å cryo-EM structure.
Use Cases
Benchmarking covalent inhibitor selectivity based on chemoproteomic target engagement ratios.
Studying HMGCS1 inhibition effects on HMG-CoA levels and protein deprenylation mentioned in the description.
Comparing cell line-specific anticancer activity patterns of pathway-specific inhibitors versus statins.
Developing frameworks for rigorous off-target profiling of covalent inhibitors in probe development.
Strengths
Includes a 2.29 Å cryo-EM structure detailing inhibitor binding within HMGCS1's hydrophobic pocket.
Data was generated using orthogonal chemoproteomic methods (enrichment and scavenging proteomics) for unbiased profiling.
File size is 2.0 MB, indicating a focused and likely manageable dataset for analysis.
Limitations
Row count is unknown, which may limit suitability assessment for large-scale ML tasks.
Column-level documentation is absent; field semantics must be inferred after download.
Description metadata is limited; actual data quality and completeness require manual inspection.
Provenance
Source
figshare
Collection Method
Integrating orthogonal chemoproteomic methods, including scavenging proteomics analyzing de-enriched fractions.
Freshness
Last updated 2026-05-13 18:04:59; freshness should be verified.
License is CC-BY-NC-4.0, which prohibits commercial use.